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Oxidative stress and inflammation are hallmarks of cardiovascular disease, obesity, and metabolic syndrome. Not surprisingly, intake of fresh fruits, vegetables, and other sources of protective antioxidants tend to be insufficient in individuals suffering from these same preventable chronic diseases.
Evaluation of oxidative stress and antioxidant status of 959 adults without hypertension, diabetes, or dyslipidemia was performed. Results revealed that oxidative stress markers correlated positively with age, gamma-glutamyltransferase, ferritin, and smoking; and negatively with drinking habits, and alpha-tocopherol. Total antioxidant status correlated significantly with antioxidant compounds uric acid, folate, vitamin A and the branched chain amino acid valine.[i]
Oxidative stress is a factor in type 2 diabetes (T2D) and in cardiovascular disease, the cause of death in ~65% of T2D patients. A review of the literature reveals that[ii]
Markers of systemic oxidative stress and inflammation were significantly elevated in obese subjects compared to nonobese controls. Increased markers included hsCRP, malondialdehyde, oxidized a1-antiproteinase, as well as increased ratio of oxidized to reduced glutathione. Markers were highest in obese individuals expressing additional characteristics of metabolic syndrome (hyperglycemia, hypertension, and atherogenic dyslipidemia). The presence of increased oxidative stress and inflammation in obese individuals increases risk of atherosclerosis and type 2 diabetes.[iii]
A cross-sectional study of 48 normal-weight and 40 obese adults found that markers of oxidative stress were lowest in normal-weight subjects while oxidized LDL, CRP, TNF-alpha, and IL-18 were significantly higher in obese subjects, especially in obese subjects with metabolic syndrome versus those without it.[iv]
Clearly, it is imperative to address oxidative stress when evaluating risk for cardiometabolic disease…otherwise a keystone piece of the puzzle will be missing.
Up Next - Oxidative Stress part 5 - the Cholesterol Connection
[i] Oda, Kanae et al. “Uric acid, ferritin and γ-glutamyltransferase can be informative in prediction of the oxidative stress.” Journal of clinical biochemistry and nutrition vol. 64,2 (2019): 124-128. doi:10.3164/jcbn.18-23
[ii] Robson, Roy et al. “Oxidative stress biomarkers in type 2 diabetes mellitus for assessment of cardiovascular disease risk.” Diabetes & metabolic syndrome vol. 12,3 (2018): 455-462. doi:10.1016/j.dsx.2017.12.029
[iii] Skalicky, Jiri et al. “Evaluation of oxidative stress and inflammation in obese adults with metabolic syndrome.” Clinical chemistry and laboratory medicine vol. 46,4 (2008): 499-505. doi:10.1515/CCLM.2008.096
[iv] Van Guilder, Gary P et al. “Influence of metabolic syndrome on biomarkers of oxidative stress and inflammation in obese adults.” Obesity (Silver Spring, Md.) vol. 14,12 (2006): 2127-31. doi:10.1038/oby.2006.248