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what are some of the causative factors that get someone down the road to diabetes? Read part 2 of our ODX Insulin Resistance Series to find out.
The road to insulin resistance and diabetes is paved with added sugar, processed food, micronutrient insufficiencies, and a sedentary lifestyle.
This same path may also lead to other complications including metabolic syndrome, polycystic ovary syndrome (PCOS), non-alcoholic steatohepatitis (NASH), and non-alcoholic liver disease (NAFLD).
Even in those with normal glucose tolerance, the presence of insulin resistance (and its major risk factors of hyperinsulinemia, increased body fat, obesity, and sedentary lifestyle) is predictive of type 2 diabetes development. 
In the United States, according to the 2020 CDC National Diabetes Statistics Report: 
A 2018 meta-analysis of 86 papers confirmed robust evidence for a variety of dietary, lifestyle, medical, biochemical, environmental, and psychosocial factors that increase risk of type 2 diabetes. 
It is not surprising that chronic inflammation may trigger insulin resistance, as evidenced by its association with inflammatory biomarkers. 
"The symbol ↑ denotes a higher exposure to a risk factor, and the symbol ↓ represents a lower exposure to a risk factor. For alcohol consumption, never drinkers presented a higher risk for T2DM than moderate drinkers."
Source: Bellou, Vanesa et al. “Risk factors for type 2 diabetes mellitus: An exposure-wide umbrella review of meta-analyses.” PloS one vol. 13,3 e0194127. 20 Mar. 2018.
Patients traveling down this road may think that the milepost for prediabetes is inconsequential. However, complications of prediabetes include heart disease and stroke and these complications extend in diabetes to kidney failure, blindness, and lower extremity amputation. 
Health is priceless and no degree or stage of disease is inconsequential. Making even small changes in diet, nutrition, and physical activity will be well worth the investment.
 Gutch, Manish et al. “Assessment of insulin sensitivity/resistance.” Indian journal of endocrinology and metabolism vol. 19,1 (2015): 160-4.
 National Diabetes Statistics Report 2020.
 Bellou, Vanesa et al. “Risk factors for type 2 diabetes mellitus: An exposure-wide umbrella review of meta-analyses.” PloS one vol. 13,3 e0194127. 20 Mar. 2018.
 Khan, Haseeb A et al. “Biomarker potential of C-peptide for screening of insulin resistance in diabetic and non-diabetic individuals.” Saudi journal of biological sciences vol. 25,8 (2018): 1729-1732.
 National Center for Chronic Disease Prevention and Health Promotion: Diabetes. [CDC Website].