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Welcome to episode 4 of "Optimal - The Podcast" recorded May 13th, 2020. In part 2 we cover an update on Vitamin D.
Dr. Michael Holick, Ph.D., M.D. Professor of Medicine, Physiology and Biophysics; Director of the General Clinical Research Unit; and Director of the Bone Health Care Clinic and the Director of the Heliotherapy, Light, and Skin Research Center at Boston University Medical Center. Dr. Holick believes that maintaining a level of 40 to 60 ng/ml is desirable in the general population and a level up to 100 ng/ml is “perfectly safe.” [Vitamin D Society]
Others urge caution about going above 50 ng/ml. “The data are not clear cut, but some evidence of toxicity has been associated with levels above 50 ng/ ml, including hypercalcemia and kidney stones,” says Clifford Rosen, MD, director of clinical and translational research at the Maine Medical Center Research Institute, who worked on the IOM guideline.
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Sadat-Ali M, Al-Anii FM, Al-Turki HA, et al. Maintenance Dose of Vitamin D: How Much Is Enough? J Bone Metab. 2018 Aug;25(3):161-164. [R]
Vitamin D Society [R]
Just Right: How Much Vitamin D is Enough? BY ERIC SEABORG NOV 2014 [R]
Manson JE, Cook NR, Lee IM, et al; VITAL Research Group. Vitamin D Supplements and Prevention of Cancer and Cardiovascular Disease. N Engl J Med. 2019 Jan 3;380(1):33-44. [R]