ODX Biomarkers

Ratio of IL-6 to IL-10 Dicken Weatherby, N.D. and Beth Ellen DiLuglio, MS, RDN, LDN Research suggests that evaluating the ratio of IL-6 to IL-10 may be more clinically useful than measuring either cytokine alone.

Interleukin-10 (IL-10) Dicken Weatherby, N.D. and Beth Ellen DiLuglio, MS, RDN, LDN Interleukin-10 is an anti-inflammatory cytokine that curbs IL-6, TNF-alpha, and IL-8 pro-inflammatory activity. [1]

Interleukin-6 (IL-6) Dicken Weatherby, N.D. and Beth Ellen DiLuglio, MS, RDN, LDN Interleukin-6 is one of a number of compounds in the IL-6 family which includes IL-11, IL-27, IL-31, and other metabolically active compounds. [1]

How to correct B12 deficiency, choosing the right type of B12, dosage, food sources, etc. Dicken Weatherby, N.D. and Beth Ellen DiLuglio, MS, RDN, LDN Is the current RDA enough? The RDA Dietary Reference Intake (DRI) for vitamin B12 is 2.4 ug/day for non-pregnant, non-lactating adults.[1]

Biomarkers and how we can assess for B12 deficiency Dicken Weatherby, N.D. and Beth Ellen DiLuglio, MS, RDN, LDN A full clinical assessment of B12 status includes review of signs and symptoms as well as extended blood chemistry analysis. Assessment of B12 status can be complex because: [1]

The road to B12 deficiency and what happens when we get there… Dicken Weatherby, N.D. and Beth Ellen DiLuglio, MS, RDN, LDN Elderly status, strict vegetarianism, and lack of intrinsic factor have been traditionally recognized as the main causes of B12 deficiency.[1]

Vitamin B12 Biochemistry and Physiology Dicken Weatherby, N.D. and Beth Ellen DiLuglio, MS, RDN, LDN Vitamin B12, a cobalt-containing compound known as cobalamin, is synthesized by bacteria yet essential to humans. The term cobalamin is a generic term for corrinoids (containing a corrin nucleus).[1]

We are excited to announce that we have added over 35 new biomarkers into the Optimal DX software application. Please watch this short video explaining the biomarkers and how to use the Lab Templates to feature these in your Functional Health Reports:

QUICKI – An Additional Index for Assessing Insulin Resistance in Our Patients Dicken Weatherby, N.D. and Beth Ellen DiLuglio, MS, RDN, LDN QUICKI (Quantitative Insulin Sensitivity Check Index), a variation of HOMA2, is a simple calculation that uses fasting glucose and fasting insulin to assess insulin sensitivity and show the degree of insulin resistance.

HOMA2 - IR: An Index For Assessing the Degree of Insulin Resistance Dicken Weatherby, N.D. and Beth Ellen DiLuglio, MS, RDN, LDN Insulin resistance is a term used to indicate the failure of the peripheral tissue cells to respond appropriately to insulin, therefore impairing their capacity to uptake glucose from the blood stream, and resulting in an increased serum blood glucose level.