We find that not all activity is good, especially if it is lipoprotein-associated phospholipase A2 (Lp-PLA2) activity. This activity reflects increased oxidative stress, inflammation, atherosclerosis, and the risk of diabetes and cardiovascular disease.
An increase in Lp-PLA2 activity reflects greater atherosclerotic plaque severity and a higher risk of rupture. It may also reflect an increased risk of aortic stenosis and stroke.
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