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April 27, 2022

HOMA2-IR Reflects Insulin Sensitivity and Resistance

Optimal Takeaways

Homeostatic Model Assessment (HOMA) utilizes results from fasting glucose, insulin, and/or C-peptide. It calculates how cells are responding to or resisting insulin, and how well the beta cells of the pancreas are working.

The HOMA2-IR calculation assesses the likelihood of insulin resistance and, potentially, the risk of metabolic syndrome, diabetes, and heart failure.  

An elevated HOMA-IR in those with diabetes may also indicate an increased risk of complications including cardiovascular complications. Insulin resistance may be associated with vitamin D insufficiency, which should also be assessed regularly.

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Tag(s): Biomarkers

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