The HOMA2-%B calculation helps estimate beta-cell function and insulin production. An elevation in HOMA2-%B means increased beta-cell activity and increased production of insulin.
If cells remain resistant to the extra insulin, beta cells may eventually begin to fail, insulin production will decrease, and blood glucose will remain elevated. This is the road to type 2 diabetes.
Evaluating beta-cell function and insulin metabolism helps determine where an individual may be on the spectrum of blood glucose dysregulation. In the early phases, nutrition and lifestyle changes can reverse the trend toward diabetes and its ultimate offspring cardiovascular disease.