Fructosamine is a compound in the blood that reflects high blood glucose over the past 2-4 weeks. It is formed via glycosylation or "glycation," the binding of glucose or fructose to proteins in the blood. It primarily reflects glycated albumin but also represents glycation of lipoproteins and globulin.
Elevated fructosamine is a sign of abnormal blood glucose regulation that should be addressed early on as it can impair how these proteins function. Increasing fructosamine is associated with increasing fasting glucose and hemoglobin A1C. However, fructosamine may be a better indicator of type 2 diabetes risk than hemoglobin A1C, especially in those with hemoglobin abnormalities such as anemia and sickle cell disease.
Levels of fructosamine can be successfully reduced with nutrition intervention, especially with balanced meals and moderation of carbohydrate intake.