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Ongoing research confirms the association between elevated fibrinogen and adverse outcomes, including cardiovascular disease, stroke, and vascular and nonvascular mortality. Fibrinogen is associated with inflammatory disorders and is considered a biomarker of inflammation.
Increasing fibrinogen is also associated with neurological disorders, brain trauma (Petersen 2018), and exposure to pollution. Fortunately, maintaining a blood level of omega-3s above 5.12% significantly reduces the fibrinogen increase observed with pollution exposure (Croft 2018).
We are updating the ODX Optimal Range for fibrinogen to better reflect the current research. Studies indicate that the risk of more severe cardiovascular disease increases as fibrinogen levels increase above 300 mg/dL (8.82 umol/L) (Ang 2017, Danesh 2005, Liu 2020).
The new ODX Optimal Range for fibrinogen is 175 - 300 mg/dL (5.15 - 8.82 umol/L).
CLICK HERE to read more about the research and reasoning behind monitoring fibrinogen levels from the ODX Research Blog.
Ang, Lawrence et al. “Elevated Baseline Serum Fibrinogen: Effect on 2-Year Major Adverse Cardiovascular Events Following Percutaneous Coronary Intervention.” Journal of the American Heart Association vol. 6,11 e006580. 18 Nov. 2017, doi:10.1161/JAHA.117.006580
Croft, Daniel et al. “Do elevated blood levels of omega-3 fatty acids modify effects of particulate air pollutants on fibrinogen?.” Air quality, atmosphere, & health vol. 11,7 (2018): 791-799. doi:10.1007/s11869-018-0586-0
Danesh J, Lewington S, Thompson SG, et al. Plasma fibrinogen level and the risk of major cardiovascular diseases and nonvascular mortality: an individual participant meta-analysis. JAMA. 2005 Oct 12;294(14):1799-809.
Liu, Junxiu et al. “Associations of C-reactive protein and fibrinogen with mortality from all-causes, cardiovascular disease and cancer among U.S. adults.” Preventive medicine vol. 139 (2020): 106044. doi:10.1016/j.ypmed.2020.106044
Petersen, Mark A et al. “Fibrinogen in neurological diseases: mechanisms, imaging and therapeutics.” Nature reviews. Neuroscience vol. 19,5 (2018): 283-301. doi:10.1038/nrn.2018.13