ODX Biomarkers

How to correct B12 deficiency, choosing the right type of B12, dosage, food sources, etc. Dicken Weatherby, N.D. and Beth Ellen DiLuglio, MS, RDN, LDN Is the current RDA enough? The RDA Dietary Reference Intake (DRI) for vitamin B12 is 2.4 ug/day for non-pregnant, non-lactating adults.[1]

Biomarkers and how we can assess for B12 deficiency Dicken Weatherby, N.D. and Beth Ellen DiLuglio, MS, RDN, LDN A full clinical assessment of B12 status includes review of signs and symptoms as well as extended blood chemistry analysis. Assessment of B12 status can be complex because: [1]

The road to B12 deficiency and what happens when we get there… Dicken Weatherby, N.D. and Beth Ellen DiLuglio, MS, RDN, LDN Elderly status, strict vegetarianism, and lack of intrinsic factor have been traditionally recognized as the main causes of B12 deficiency.[1]

Vitamin B12 Biochemistry and Physiology Dicken Weatherby, N.D. and Beth Ellen DiLuglio, MS, RDN, LDN Vitamin B12, a cobalt-containing compound known as cobalamin, is synthesized by bacteria yet essential to humans. The term cobalamin is a generic term for corrinoids (containing a corrin nucleus).[1]

We are excited to announce that we have added over 35 new biomarkers into the Optimal DX software application. Please watch this short video explaining the biomarkers and how to use the Lab Templates to feature these in your Functional Health Reports:

QUICKI – An Additional Index for Assessing Insulin Resistance in Our Patients Dicken Weatherby, N.D. and Beth Ellen DiLuglio, MS, RDN, LDN QUICKI (Quantitative Insulin Sensitivity Check Index), a variation of HOMA2, is a simple calculation that uses fasting glucose and fasting insulin to assess insulin sensitivity and show the degree of insulin resistance.

HOMA2 - IR: An Index For Assessing the Degree of Insulin Resistance Dicken Weatherby, N.D. and Beth Ellen DiLuglio, MS, RDN, LDN Insulin resistance is a term used to indicate the failure of the peripheral tissue cells to respond appropriately to insulin, therefore impairing their capacity to uptake glucose from the blood stream, and resulting in an increased serum blood glucose level. 

HOMA2 - %B: An Index For Gauging the Beta Cell Output of Insulin from the Pancreas Dicken Weatherby, N.D. and Beth Ellen DiLuglio, MS, RDN, LDN The beta cells of the pancreatic islets are responsible for production and secretion of insulin. Beta cells have a small capacity to store insulin, and the stored insulin is secreted immediately upon elevation of blood glucose levels, causing a resultant short-term increase in blood insulin levels.

HOMA2 - %S: An Index For Assessing Cellular Sensitivity to Insulin Dicken Weatherby, N.D. and Beth Ellen DiLuglio, MS, RDN, LDN Insulin sensitivity is a term used to indicate the responsiveness of the peripheral tissue cells to insulin, and their resultant capacity to uptake glucose out of the bloodstream.

The HOMA2 Calculator: An Important Series of Indices for Gauging Insulin Resistance Dicken Weatherby, N.D. and Beth Ellen DiLuglio, MS, RDN, LDN Insulin sensitivity reflects the responsiveness of peripheral tissues to insulin and their ability to take up circulating glucose. When cells are less responsive to insulin, beta cells produce more insulin to compensate, creating a vicious cycle of increased production of insulin and an increased resistance to insulin at the cellular level, a condition called Insulin Resistance.