Optimal - The Blog

December 1, 2025

Supplements Support a Leaky Gut

The intestinal barrier is a crucial part of the body’s defense system, designed to selectively absorb nutrients while keeping out harmful bacteria, toxins, and other harmful substances. It is composed of four key components: the microbiota, mucus, the intestinal lining, and immune cells.

However, factors such as medications, pollutants, stress, alcohol, and infections can weaken the barrier, increasing permeability.

This condition, known as intestinal hyperpermeability, allows harmful substances to enter the bloodstream, potentially triggering systemic inflammation, hormonal imbalances, and chronic conditions like autoimmune diseases.

To support and repair the intestinal barrier, certain supplements can be helpful.

  • Probiotics can restore microbial balance and improve gut health.
  • Glutamine aids in repairing the intestinal lining and reducing permeability, especially at higher doses.
  • Vitamins A and D are essential for maintaining gut barrier integrity, regulating immune cells, and preventing dysbiosis.

Supplements can help improve microbial balance, protect and repair the intestinal epithelium, and enhance the expression and function of tight-junction proteins.

Want to Learn More?

OPTIMAL DX MEMBERS CLICK HERE to learn more about Supplements for a leaky gut, health consequences, etc.

New call-to-action

Other posts you might be interested in