Optimal - The Blog

April 4, 2024

SPE not SPF for Evaluating Serum Proteins

Serum protein electrophoresis (SPE) is a lab test that separates proteins in the blood to help diagnose various health conditions.

It can detect changes in protein levels associated with inflammation, liver or kidney failure, and certain cancers like multiple myeloma.

The test looks at different protein fractions, including albumin and globulins, to identify any abnormal patterns.

SPE results can indicate a range of issues, from acute reactions like infections to chronic conditions such as nephrotic syndrome or liver failure:

    • Acute reactions Including infections, necrosis, burns, surgery, stress, MI
    • Nephrotic syndrome
    • Advanced cirrhosis
    • Polyclonal gamma globulin elevation
    • Monoclonal gammopathy
    • Anemia: Iron deficiency
    • Antibody deficiency
    • Inflammation: Acute in the early stages
    • Inflammation: Acute in the latter stages
    • Inflammation: Chronic
    • Inflammation: Chronic, active
    • Liver failure
    • Malignant tumors
    • Nephrotic syndrome
    • Pregnancy

Understanding the specific protein changes can help doctors figure out the underlying cause and guide further testing or treatment.

Want to Learn More? 

CLICK HERE to learn more about Serum Protein Electrophoresis, health associations, etc.

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