Optimal - The Podcast: Episode 6

Optimal - The Podcast: Episode 6

Dr. Dicken Weatherby & Beth Ellen DiLuglio, MS, RDN, LDN

Welcome to episode 6 of "Optimal - The Podcast" recorded July 10th, 2020.

Here's a breakdown of what we covered and timing:

Introduction (00:00:00)
Personal COVID-19 Update (00:02:59)
Oxidative Stress – Intro (00:07:17)
Glutathione, Oxidative Stress & COVID-19 (00:17:07)
Oxidative Stress – Biomarkers (00:30:43)
New Ask Me Anything (AMA) Feature (00:34:15)
AMA Q1 - What if a patient is close to being outside the functional range how would you interpret that pattern? (00:35:00)
AMA Q2 - What is the time frame that you would consider blood test results clinically relevant? (00:37:57)
AMA Q3 - I get quite a few patients coming with blood work from other doctors and there are often very few biomarkers on these panels compared to what you recommend. How do I use the software for this? (00:41:31)
AMA Q4 - If someone has high amylase and lipase in their blood results - what can this mean? (00:46:15)
AMA Q5 - Will eosinophils be elevated with an H.Pylori infection? (00:50:35)
ODX Biomarkers – Adiponectin (00:52:32)
ODX Biomarkers – Active B12 (01:00:11)
ODX Biomarkers – Selenium (01:05:32)
ODX Biomarkers – Free T3:Free T4 Ratio (01:09:50)

Research Studies and Links

Correlation between Oxidative Stress, Nutrition, and Cancer Initiation


Saha, Subbroto Kumar et al. “Correlation between Oxidative Stress, Nutrition, and Cancer Initiation.” International journal of molecular sciences vol. 18,7 1544. 17 Jul. 2017,  [R]


Nutrients and plant-based compounds support glutathione production and activity
Minich, Deanna M, and Benjamin I Brown. “A Review of Dietary (Phyto)Nutrients for Glutathione Support.” Nutrients vol. 11,9 2073. 3 Sep. 2019, [R]

Dr. Pizzorno’s review article on Glutathione

Pizzorno, Joseph. “Glutathione!.” Integrative medicine (Encinitas, Calif.) vol. 13,1 (2014): 8-12. [R] 

Glutathione, oxidative stress, and COVID-19


Polonikov, Alexey. “Endogenous Deficiency of Glutathione as the Most Likely Cause of Serious Manifestations and Death in COVID-19 Patients.” ACS infectious diseases, acsinfecdis.0c00288. 28 May. 2020 [R]

Additional Oxidative Stress Information

Cholesterol acts as an antioxidant
Butterfield, J D Jr, and C P McGraw. “Free radical pathology.” Stroke vol. 9,5 (1978): 443-5. [R]

Smith, L L. “Another cholesterol hypothesis: cholesterol as antioxidant.” Free radical biology & medicine vol. 11,1 (1991): 47-61. [R]

ODX Biomarker Articles


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