Optimal - The Blog

September 15, 2023

Lipoprotein Ratios Matter: Apo B to Apo A-1

The ratio between Apo B (associated with LDL and atherogenic) and Apo A-1 (associated with HDL and protective) is a key indicator for assessing the risk of cardiovascular diseases (CVD), including advanced atherosclerosis, myocardial infarction (MI), stroke, metabolic syndrome, and diabetic complications.

A low Apo B to Apo A-1 ratio signifies decreased CVD risk due to reduced atherogenic Apo B and increased protective Apo A-1.

Conversely, a high ratio increases the risk of various cardiometabolic disorders.

Studies have found that this ratio is a better tool for evaluating coronary artery disease than traditional biomarkers like total cholesterol or lipid ratios.

A ratio of 0.865 or above is considered a significant independent risk factor, tripling the risk of major cardiovascular events. This ratio is also significantly correlated with the severity of atherosclerosis and has been associated with metabolic syndrome risk.

Want to Learn More?

CLICK HERE to learn more about ApoB:A-1 Ratio, health consequences, the ODX ranges, etc.


Tag(s): Biomarkers

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