Very low-density lipoproteins (VLDL) transport triglycerides throughout the body and play a significant role in developing insulin resistance, metabolic syndrome, and type 2 diabetes.
Overproduction of large triglyceride-rich VLDLs contributes to atherogenic changes, with factors such as fatty acid availability, circulating glucose, brain glucose sensing, and insulin sensitivity influencing their production.
Large VLDLs are precursors to small, dense LDL particles, which are associated with increased atherosclerosis risk. Large VLDL levels can be modulated by factors like diet, omega-3 fatty acids, and weight management.
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