Globulins ... You Can't Live Without Them

Globulins are not ghosts or goblins... they are proteins in your blood. The total globulin level is calculated by subtracting albumin from the total protein value. 

Total globulin reflects all non-albumin proteins in circulation, including transport proteins such as thyroid-binding globulin, ceruloplasmin, transferrin, and lipoproteins. Immunoglobulins (gamma globulins AKA antibodies) and complement proteins are also globulins and counted in the total globulin value.

Many globulin proteins are produced by the liver, but gamma globulin antibodies are produced by lymphocytes, a type of white blood cell, 

Low total globulin levels are associated with immune deficiency disorders and lead exposure. High total globulin levels are associated with immune activity, infection, inflammation, liver disease, diabetes, cancer, nephrotic syndrome, and rheumatoid disease.

Research suggests that elevated total globulin may be considered a nonspecific marker of systemic inflammation.

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