Optimal - The Blog
August 6, 2025
Endothelial dysfunction occurs when the thin layer of cells lining blood vessels, known as the endothelium, is damaged by factors such as high blood sugar, oxidative stress, certain medications, or toxins like homocysteine.
This damage impairs blood vessel function, increases inflammation and oxidative stress, and raises the risk of heart attacks, strokes, and other chronic conditions.
Unhealthy lifestyle choices, such as a poor diet and lack of exercise, can exacerbate this condition.
However, treatments that target the underlying issues can improve vascular health and lower the risk of long-term complications.
- Certain supplements can support endothelial health.
- In various studies, Curcumin, at doses ranging from 150 mg to 2,000 mg daily, has been shown to improve blood vessel function.
- Vitamins C and E, when taken together, also enhance endothelial function by improving blood vessel dilation.
- Arginine, an amino acid, may help reduce blood pressure and improve vascular health, particularly when combined with other nutrients, such as B vitamins.
- Coenzyme Q10 (100 to 300 mg daily) has been shown to enhance endothelial function and increase beneficial nitric oxide levels, supporting overall vascular health.
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