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Magnesium is the fourth most abundant mineral and the second most abundant intracellular divalent cation.
It acts as a cofactor for more than 300 metabolic reactions, such as ATP (energy) production, protein synthesis, DNA/RNA synthesis, and mitochondrial function
Chronic magnesium deficiency contributes to the development and progression of heart failure, hypertension, atherosclerotic vascular disease, and metabolic diseases.
Acute magnesium deficiency has been shown to be associated with cardiac arrhythmia and neuromuscular hyper-excitability (such as pre-eclampsia and epilepsy).
Recommended dietary allowances of Mg for adults are 400–420 mg for men and 310–320 mg for women
People who had the highest daily Mg intake (~191 mg Mg/1000 kcal) had significantly higher HDL cholesterol, lower blood glucose, lower fasting insulin levels, and lower blood pressure, compared with people who had the lowest daily Mg intake (~96 mg/1000 kcal)
Increasing dietary Mg intake (per 100 mg/day increment) is linked to a 22% reduction in the risk of heart failure, as well as reduced risks of all-cause mortality, stroke, and type 2 diabetes
Liu, Man, and Samuel C Dudley Jr. “Magnesium, Oxidative Stress, Inflammation, and Cardiovascular Disease.” Antioxidants (Basel, Switzerland) vol. 9,10 907. 23 Sep. 2020, doi:10.3390/antiox9100907 This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).