Optimal - The Blog

April 1, 2024

The 1,2 Punch of Active 1,25 Vitamin D

Calcitriol, the active hormone form of vitamin D, is crucial for bone health, immune function, and controlling inflammation. It is produced in the body from vitamin D through processes involving the liver and kidneys, and other tissues like bone and the immune system also contribute.

Low levels of calcitriol are linked to various health issues, including bone, liver, kidney diseases, cardiovascular disorders, and metabolic syndrome. High levels, on the other hand, can indicate conditions like excessive calcium, granulomatous disorders, or signs of vitamin D toxicity.

While calcitriol is not the primary marker for vitamin D status, its measurement can be important in certain medical conditions like kidney disease or where there's abnormal vitamin D metabolism. It has a short half-life and its levels are influenced by hormones like parathyroid hormone, calcium, and phosphate.

Beyond its traditional roles, emerging research suggests calcitriol may have benefits in immune support and managing conditions like metabolic syndrome, hypertension, and certain pregnancy complications. However, excessively high levels might indicate autoimmune disorders or other health issues, necessitating careful monitoring and management.

Want to Learn More? 

CLICK HERE to learn more about 1,25(OH)2D, health consequences, the ODX ranges, etc.

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Tag(s): Biomarkers

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