Diabetes mellitus (DM) is a condition marked by high blood sugar and, in some cases, low blood sugar when poorly managed. It significantly affects brain function because the brain relies on a steady supply of glucose for energy.
In people with diabetes, changes in how glucose is processed can lead to problems with memory, decision-making, and overall cognitive function. This is due to several factors, including poor blood flow to the brain, insulin resistance in brain tissue, and repeated episodes of low blood sugar that can damage brain cells.
As a result, people with diabetes—especially those over 60, with long-term diabetes or poor blood sugar control—are at a higher risk for cognitive decline and dementia.
Other risk factors include high blood pressure, high cholesterol, inactivity, and depression. In fact, research shows that individuals with diabetes are 1.25 to 1.91 times more likely to develop cognitive impairment or dementia compared to those without the condition.
Managing diabetes well is especially important because cognitive decline can make it harder for people to take care of their condition, creating a cycle that worsens both brain and physical health.
This makes early recognition and careful treatment essential. Supporting healthy blood sugar levels, encouraging regular activity, and addressing other risk factors may help protect brain health in people with diabetes.
Sebastian, Meghna Julian et al. “Diabetes and cognitive function: An evidence-based current perspective.” World journal of diabetes vol. 14,2 (2023): 92-109. doi:10.4239/wjd.v14.i2.92.
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