Optimal - The Blog

September 1, 2025

Collagen Peptides for Joint Health

Collagen peptides (the broken-down form of supplemental collagen) seem most helpful for joints when paired with regular exercise.

Across research studies, people—mainly recreational athletes, plus some older adults—reported less activity-related joint pain, better joint function, and more pain-free exercise time after a few months of daily collagen.

The likely reason is that collagen and training support the connective tissues (cartilage, tendons, ligaments) that keep joints stable.

Higher doses (about 15 g, often with vitamin C) can boost collagen production—especially if taken ~60 minutes before workouts—but whey or similar high-quality proteins do a better job of stimulating muscle protein synthesis because they contain a complete array of essential amino acids.

Collagen lacks the essential amino acid tryptophan, though collagen peptide supplements with added tryptophan are available.

Overall, collagen was well tolerated in studies, and benefits tended to show up after ~3 months of steady use.

 

  • Best use: Collagen + exercise is most reliable for reducing joint pain and improving joint function.
  • How to take: Aim for 5–15 g/day, ideally ~1 hour pre-workout, and stick with it for ≥3 months for noticeable effects.
  • For muscle gains: Choose whey or other complete proteins for hypertrophy; collagen alone is not as effective for building muscle.
  • Safety: Generally well tolerated in trials; expect modest improvements in body composition and recovery when combined with training.

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