Albumin and globulin proteins make up the total protein value in your blood. However, assessing the ratio of albumin to globulin (A/G ratio) can provide more detailed information about different systems in the body. The A/G ratio is normally above 1 as albumin constitutes the majority of protein in circulation.
A low A/G ratio is often associated with liver dysfunction, critical illness, and immune activation. Low A/G has been associated with liver disease, chronic inflammation, cognitive decline, rheumatoid arthritis, and infection. A lower ratio has also been associated with decreased bone mineral density and may be a useful screening tool for osteoporosis. A low A/G ratio in critical illness has been associated with poorer outcomes and decreased survival.
An elevated A/G ratio is not as common but may be associated with dehydration.
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