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Stress Changes Your Body: What Cortisol and DHEA-S Can Tell You

Written by ODX Admin | Aug 20, 2026, 7:30:00 AM

Discover how cortisol and DHEA-S reveal your body's response to stress and the importance of hormonal balance for health and aging. Learn more today.

Stress is part of life, but when it becomes chronic and unmanageable, it can affect much more than mood.

Long-term stress influences hormones, immune function, metabolism, and even the aging process.

Scientists are increasingly studying two hormones—cortisol and DHEA-S—to better understand how the body responds to stress.

The Body's Stress Hormones

Cortisol helps the body respond to physical and emotional challenges while supporting many normal functions, including metabolism and immune health.

DHEA-S is another hormone produced by the adrenal glands that helps balance some of cortisol's effects and supports healthy brain and immune function.

Why Balance Matters

As people age, DHEA-S levels naturally decline, while cortisol levels remain relatively steady. Researchers believe this shift may make it harder for the body to recover from stress and maintain normal physiological balance. Chronic stress may further reduce DHEA-S, leaving cortisol's effects less balanced.

Looking Beyond One Hormone

Measuring cortisol alone may not provide a complete picture because hormone levels naturally fluctuate throughout the day.

Researchers are finding that comparing cortisol with DHEA-S may offer better insight into how well the body adapts to stress. A healthier balance between the two hormones has been linked with greater resilience and healthy aging.

Stress affects many systems throughout the body, but it also changes hormone patterns that can be measured.

Looking at cortisol and DHEA-S together may provide a better understanding of the body's response to chronic stress and support a more complete picture of overall health.

Want to Learn More?

OPTIMAL DX MEMBERS CLICK HERE to learn more about the HPA axis, Cortisol, DHEA-S, and their health consequences and benefits.