Nutrition Support Should Be Targeted

Every individual has unique nutritional needs, and nutrition supplementation should be targeted based on specific needs.

Biomarker-guided approaches use laboratory tests, such as genetic, proteomic, metabolomic, lipidomic, microbiome, and immunological markers, to identify actual nutrient insufficiencies and metabolic imbalances, enabling targeted and more effective supplementation.

For instance, an MTHFR gene variant may impair folate metabolism, indicating a need for methylated folate forms; an unfavorable lipid profile may indicate a need for omega‑3 fatty acid supplementation; alterations in gut microbial composition may suggest a need for specific probiotics; and elevated cortisol or CRP levels may indicate a need for magnesium or anti‑inflammatory compounds like curcumin.

This precision nutrition strategy replaces one‑size‑fits‑all supplement regimens with data-driven prescriptions, reducing the risk of overdosing and unnecessary supplementation. Regular follow-up testing allows ongoing assessment and fine‑tuning of nutrient intake as biomarker levels normalize.

In summary, biomarker‑guided supplementation offers a smarter, safer, and more effective way to support health by aligning supplement choices and dosages with measurable individual physiological needs.

Reference

Pokushalov, Evgeny et al. “Biomarker-Guided Dietary Supplementation: A Narrative Review of Precision in Personalized Nutrition.” Nutrients vol. 16,23 4033. 25 Nov. 2024, doi:10.3390/nu16234033 This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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