Non-HDL cholesterol, calculated by subtracting HDL-C from total cholesterol, includes all circulating cholesterol except HDL-C and is closely linked to cardiovascular disease (CVD) risk.
Higher non-HDL-C levels are associated with arterial stiffness, ischemic heart disease, stroke, and major adverse cardiovascular events. Compared to LDL-C, non-HDL-C may provide a more accurate prediction of CVD risk, even in patients under statin treatment.
Furthermore, a high non-HDL-C to HDL-C ratio may suggest non-alcoholic fatty liver disease.
Despite its benefits, a non-HDL cholesterol assessment does not provide information about particle size and number or oxidation status, all relevant to evaluating CVD risk.
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