Methylmalonic acid (MMA) is linked to vitamin B12 insufficiency and can also indicate issues such as oxidative stress and mitochondrial dysfunction. It is not a standalone biomarker for B12 deficiency and should be assessed alongside other biomarkers.
Elevated MMA is associated with health problems like renal dysfunction, diabetes, neuropathy, migraines, and increased mortality risk. A low MMA generally means sufficient vitamin B12 levels.High MMA levels can be related to a variety of factors, including B12 insufficiency, kidney disease, metformin use, and migraines. MMA can be an early indicator of B12 insufficiency and is formed when a lack of vitamin B12 impairs specific enzymes in the body.
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