Researchers mapped how thousands of proteins change with age across many human tissues and found that aging doesn’t move in a straight line.
Instead, it tends to speed up around the late-40s to mid-50s, with blood vessels showing wear and tear earlier than most organs.
They also built new “protein age clocks” and spotted blood markers that reflect what’s happening inside organs.
- Midlife speed-up: Aging accelerates around 45–55; adrenal glands show early signs by ~30, and blood vessels (especially the aorta) age sooner and faster than most tissues.
- Protein upkeep slips: With age, protein quality control declines and amyloid-type buildup rises; genes and proteins also drift out of sync, a hallmark of aging biology.
- New testing tools: Scientists created proteomic age clocks and identified a blood signature that mirrors organ aging—potential building blocks for future health checks.
- What to do now: Start early on the basics—regular exercise, nutritious diet, good sleep, stress management, and not smoking—to support vascular and whole-body healthy aging.
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