People who lived to be 100 showed healthier blood marker patterns many years before reaching old age. Starting as early as their mid-60s, they tended to have higher levels of total cholesterol and iron, and lower levels of glucose, creatinine, uric acid, and several liver-related markers.
These patterns suggest differences in metabolism, kidney function, inflammation, and nutrition long before the end of life.
In this long-term study of more than 44,000 adults, almost all measured blood markers were associated with the likelihood of reaching age 100.
Lower levels of creatinine, uric acid, and several liver markers were especially common in people who lived the longest. Only two markers—alanine aminotransferase and albumin—did not show a meaningful relationship with reaching age 100.
People who became centenarians also showed fairly similar overall blood marker patterns. Two subgroups were identified, but they mainly differed in nutritional markers like total cholesterol, albumin, and iron-binding measures.
Despite these small differences, the group of centenarians as a whole looked clearly different from people who did not reach age 100.
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