Biomarker Patterns Associated with Living to 100

Researchers in Sweden tracked over 44,000 adults for up to 35 years to see which blood measures best predicted who would live to 100.

They found that, starting around age 65, future centenarians consistently had healthier blood levels of glucose, fats, organ-function markers, and inflammation indicators than their peers.

These “good” biomarker patterns showed up more than a decade before age 100 and likely reflect a mix of genetics and long-term healthy habits like balanced eating and low chronic inflammation.

Optimal Takeaways

• Stable Blood Sugar & Low Inflammation: Lower fasting glucose and uric acid levels were hallmarks of those who lived longest.
• Healthy Organ Function: Centenarians had more favorable liver and kidney markers (e.g., lower GGT, ALP, LDH, creatinine), indicating sustained organ health.
• Balanced Cholesterol & Iron: Modestly higher total cholesterol and serum iron—still within normal ranges—were linked to reaching 100.
• Good Nutrition Status: Better albumin levels and an optimal iron-to-TIBC ratio pointed to sound nutrition and anemia protection.
• Early Signals: These protective biomarker patterns appeared decades before age 100, underscoring the value of lifelong metabolic and cardiovascular care.

References

Murata, Shunsuke et al. “Blood biomarker profiles and exceptional longevity: comparison of centenarians and non-centenarians in a 35-year follow-up of the Swedish AMORIS cohort.” GeroScience vol. 46,2 (2024): 1693-1702. doi:10.1007/s11357-023-00936-w This article is licensed under a Creative Commons Attribution 4.0 International License

Murata, Shunsuke et al. “Correction to: Blood biomarker profiles and exceptional longevity: comparison of centenarians and non‑centenarians in a 35‑year follow‑up of the Swedish AMORIS cohort.” GeroScience vol. 46,2 (2024): 2793-2794. doi:10.1007/s11357-023-00996-y

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